Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium

Intravenous perhexiline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1976-07, Vol.54 (1), p.14-20
Main Authors: Klassen, G A, Sestier, F, L'Abbate, A, Mildenberger, R R, Zborowska-Sluis, D T
Format: Article
Language:English
Subjects:
Animals
Coronary Circulation - drug effects
Coronary Disease - drug therapy
Coronary Disease - physiopathology
Dogs
Lung - blood supply
Myocardium - metabolism
Oxygen Consumption
Perhexiline - pharmacology
Perhexiline - therapeutic use
Piperidines - pharmacology
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Summary:Intravenous perhexiline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic-induced left ventricular failure.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.54.1.14