The nature of the differential inhibition of polyphenylalanine synthesis in extracts from Artemia salina and rabbit reticulocytes by the Phytolacca americana protein

The difference in sensitivity of polyphenylalanine synthesis in extracts from Artemia salina and rabbit reticulocytes to inhibition by the Phytolacca americana protein (PAP) has been found to be linked to the source of the supernatant enzyme fraction and not the ribosomes. In the presence of reticul...

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Bibliographic Details
Published in:Molecular biology reports 1976-04, Vol.2 (5), p.363-367
Main Authors: Suits, J P, Irvin, J D
Format: Article
Language:English
Subjects:
Animals
Decapoda (Crustacea) - metabolism
Ethylmaleimide - pharmacology
Kinetics
Peptide Biosynthesis
Phenylalanine - metabolism
Plant Proteins - pharmacology
Protein Biosynthesis - drug effects
Rabbits
Reticulocytes - drug effects
Reticulocytes - metabolism
Ribosomes - drug effects
Ribosomes - metabolism
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Summary:The difference in sensitivity of polyphenylalanine synthesis in extracts from Artemia salina and rabbit reticulocytes to inhibition by the Phytolacca americana protein (PAP) has been found to be linked to the source of the supernatant enzyme fraction and not the ribosomes. In the presence of reticulocyte supernatant enzyme fraction polyphenylalanine synthesis in less sensitive to inhibition by PAP than that observed in the presence of A. salina supernatant enzyme fraction. The results suggest that reticulocyte elongation factor 2 is responsible for this effect.
ISSN:0301-4851
1573-4978
DOI:10.1007/BF00366257