Effect of 5-Fluorouracil on Regeneration in Tadpoles

FORMATION of a blastema or mass of rapidly proliferating mesenchymal cells in the amputation stump of amphibian larva corresponds to the fibroplasia which results in granulation tissue in other types of wound healing 1 . Although previous observations made in connexion with studies of mammalian woun...

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Bibliographic Details
Published in:Nature (London) 1963-08, Vol.199 (4893), p.617-618
Main Authors: DUMONT, ALLAN E, SOHN, NORMAN
Format: Article
Language:English
Subjects:
Animals
Anura
DNA
Fluorouracil
Humanities and Social Sciences
Larva
letter
Metabolism
multidisciplinary
Old Medline
Pharmacology
Regeneration
Science
Science (multidisciplinary)
Thymidine
Tritium
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Description
Summary:FORMATION of a blastema or mass of rapidly proliferating mesenchymal cells in the amputation stump of amphibian larva corresponds to the fibroplasia which results in granulation tissue in other types of wound healing 1 . Although previous observations made in connexion with studies of mammalian wound healing suggest that application of exogenous diffusible nucleotides of deoxyribonucleic acid (DNA) to fresh wounds accelerates fibroplasia, little is known concerning the effects of alterations in DNA precursors on this process 2 .
ISSN:0028-0836
1476-4687
DOI:10.1038/199617a0