AN INTERACTION BETWEEN BLEOMYCIN AND HUMAN SERUM: THE REACTION OF EHRLICH CELLS AND TRITICUM PLANT ROOTS TO SOME ANTINEOPLASTIC DRUGS ALONE AND IN COMBINATION WITH HUMAN SERUM

In two growth tests, one employing EHRLICH ascites tumor cells in suspension culture, the other employing intact roots of wheat (Triticum sativum LAM.), the growth inhibiting action of bleomycin (BLM) was shown to be intensified by human serum. Practical consequences of the finding are suggested. No...

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Bibliographic Details
Published in:Journal of antibiotics 1976, Vol.29(1), pp.58-64
Main Authors: HILDEN, JØRGEN, RØNNIKE, FOLKE, SCHOU, HENNING
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacology
Bleomycin - pharmacology
Carcinoma, Ehrlich Tumor - drug therapy
Cells, Cultured
Humans
Immune Sera - administration & dosage
Methotrexate - pharmacology
Plants - drug effects
Time Factors
Triticum
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Summary:In two growth tests, one employing EHRLICH ascites tumor cells in suspension culture, the other employing intact roots of wheat (Triticum sativum LAM.), the growth inhibiting action of bleomycin (BLM) was shown to be intensified by human serum. Practical consequences of the finding are suggested. No such serum-drug interaction has been demonstrated with other anti-tumor compounds, including methotrexate (MTX) and threosulphan (TRSF). Isolation of the active factor(s) in serum has not yet been attempted.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.29.58