EFFECT OF TAURINE ON RESPONSES TO NORADRENALINE, ACETYLCHOLINE AND OUABAIN IN ISOLATED AURICLES FROM DIGITALIZED GUINEA PIGS

Responses of the isolated heart from the guinea pig treated chronically with digitoxin until the T wave had disappeared were studied. The development of the abnormal ECG pattern was abolished by a simultaneous injection of taurine and digitoxin. Taurine also inhibited the change by digitoxin of the...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of pharmacology 1976/02/01, Vol.26(1), pp.105-110
Main Authors: FUJIMOTO, Seigo, IWATA, Heitaroh, YONEDA, Yukio
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Depression, Chemical
Digitoxin - pharmacology
Electrocardiography
Guinea Pigs
Heart Atria - drug effects
Heart Rate - drug effects
In Vitro Techniques
Male
Myocardium - metabolism
Norepinephrine - pharmacology
Ouabain - pharmacology
Taurine - metabolism
Taurine - pharmacology
Time Factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Responses of the isolated heart from the guinea pig treated chronically with digitoxin until the T wave had disappeared were studied. The development of the abnormal ECG pattern was abolished by a simultaneous injection of taurine and digitoxin. Taurine also inhibited the change by digitoxin of the responses to acetylcholine and ouabain but not to noradrenaline. The causal relationship between the inhibitory effect of taurine and prevention of the development of arrhythmias remains obscure.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.26.105