Specificity of Naturally Occurring Antibody in Normal Gibbon Serum

Gibbon natural antibody examined by immunoelectron microscopy reacted with the entire envelope of type C virus and with areas on the cell surface equivalent to or smaller than the diameter of a virion in gibbon and human culture cells infected with or releasing type C viruses. The antibody activity...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1976-03, Vol.191 (4232), p.1180-1183
Main Authors: Aoki, Tadao, Liu, Margaret, Walling, Mary Jane, Bushar, Grace S., Brandchaft, Phyllis B., Kawakami, Thomas G.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Viral - analysis
Antibody Specificity
Antigen-Antibody Reactions
Cell Line
Cell lines
Cultured cells
Embryonic cells
Gibbon ape leukemia virus
Hominidae - immunology
Hylobates - immunology
Leukemia, Myeloid - microbiology
Lymphocytes
Myeloid leukemia
Spleen cells
Virions
Viruses
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Summary:Gibbon natural antibody examined by immunoelectron microscopy reacted with the entire envelope of type C virus and with areas on the cell surface equivalent to or smaller than the diameter of a virion in gibbon and human culture cells infected with or releasing type C viruses. The antibody activity was absorbed completely by two cell cultures infected with gibbon ape leukemia virus and by the virus itself, and partially by normal gibbon spleen cells and dog thymus-derived cells infected with baboon endogenous type C virus, and fresh white blood cells obtained from a patient with chronic myelogenous leukemia in acute blastic crisis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1062861