Peripheral pulmonary carcinoid tumors

The light microscopic and ultrastructural features of five asymptomatic peripheral carcinoids presented as distinct pulmonary solitary nodules are described. By conventional microscopy the tumors displayed a variety of histologic patterns, the most unusual one showing tumor cells embedded in a richl...

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Bibliographic Details
Published in:Cancer 1976-04, Vol.37 (4), p.1977-1998
Main Authors: Bonikos, D. S., Bensch, K. G., Jamplis, R. W.
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Vessels - pathology
Carcinoid Tumor - blood supply
Carcinoid Tumor - pathology
Cell Membrane - ultrastructure
Cell Nucleus - ultrastructure
Cytoplasm - ultrastructure
Female
Humans
Inclusion Bodies - ultrastructure
Lung Neoplasms - blood supply
Lung Neoplasms - pathology
Male
Middle Aged
Organoids - ultrastructure
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Summary:The light microscopic and ultrastructural features of five asymptomatic peripheral carcinoids presented as distinct pulmonary solitary nodules are described. By conventional microscopy the tumors displayed a variety of histologic patterns, the most unusual one showing tumor cells embedded in a richly vascular hyalinized stroma and forming papillary structures or cystic spaces lined by low cuboidal cells which ultrastructurally bore a strong resemblance to intermediate or transitional forms between types I and II pneumocytes. A striking feature of these tumors was their rich vasculature associated with a marked perivascular sclerosis composed of basement membrane‐like material and collagen fibrils most likely produced by the increased numbers of pericytes surrounding these sclerotic vessels. The clinical implications, biologic behavior, and association of these tumors with other pulmonary neoplasms are also discussed.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197604)37:4<1977::AID-CNCR2820370450>3.0.CO;2-4