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Peripheral pulmonary carcinoid tumors

The light microscopic and ultrastructural features of five asymptomatic peripheral carcinoids presented as distinct pulmonary solitary nodules are described. By conventional microscopy the tumors displayed a variety of histologic patterns, the most unusual one showing tumor cells embedded in a richl...

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Published in:	Cancer 1976-04, Vol.37 (4), p.1977-1998
Main Authors:	Bonikos, D. S., Bensch, K. G., Jamplis, R. W.
Format:	Article
Language:	English
Subjects:	Adult Aged Blood Vessels - pathology Carcinoid Tumor - blood supply Carcinoid Tumor - pathology Cell Membrane - ultrastructure Cell Nucleus - ultrastructure Cytoplasm - ultrastructure Female Humans Inclusion Bodies - ultrastructure Lung Neoplasms - blood supply Lung Neoplasms - pathology Male Middle Aged Organoids - ultrastructure
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container_end_page	1998
container_issue	4
container_start_page	1977
container_title	Cancer
container_volume	37
creator	Bonikos, D. S. Bensch, K. G. Jamplis, R. W.
description	The light microscopic and ultrastructural features of five asymptomatic peripheral carcinoids presented as distinct pulmonary solitary nodules are described. By conventional microscopy the tumors displayed a variety of histologic patterns, the most unusual one showing tumor cells embedded in a richly vascular hyalinized stroma and forming papillary structures or cystic spaces lined by low cuboidal cells which ultrastructurally bore a strong resemblance to intermediate or transitional forms between types I and II pneumocytes. A striking feature of these tumors was their rich vasculature associated with a marked perivascular sclerosis composed of basement membrane‐like material and collagen fibrils most likely produced by the increased numbers of pericytes surrounding these sclerotic vessels. The clinical implications, biologic behavior, and association of these tumors with other pulmonary neoplasms are also discussed.
doi_str_mv	10.1002/1097-0142(197604)37:4<1977::AID-CNCR2820370450>3.0.CO;2-4
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source	EZB Electronic Journals Library
subjects	Adult Aged Blood Vessels - pathology Carcinoid Tumor - blood supply Carcinoid Tumor - pathology Cell Membrane - ultrastructure Cell Nucleus - ultrastructure Cytoplasm - ultrastructure Female Humans Inclusion Bodies - ultrastructure Lung Neoplasms - blood supply Lung Neoplasms - pathology Male Middle Aged Organoids - ultrastructure
title	Peripheral pulmonary carcinoid tumors
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