Latent Herpetic Infections Following Experimental Viraemia

Reed Neurological Research Center and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90024, U.S.A. The spectrum of tissues harbouring latent herpes simplex virus following intravenous inoculation of mice was defined by in vitro co-cultivation techniques....

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Bibliographic Details
Published in:Journal of general virology 1976-04, Vol.31 (1), p.75-80
Main Authors: Cook, Margery L, Stevens, J. G
Format: Article
Language:English
Subjects:
Adrenal Glands - microbiology
Animals
Blood - microbiology
Brain - microbiology
Ganglia, Spinal - microbiology
Herpes Simplex - microbiology
Mice
Simplexvirus - growth & development
Simplexvirus - isolation & purification
Spinal Cord - microbiology
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Summary:Reed Neurological Research Center and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90024, U.S.A. The spectrum of tissues harbouring latent herpes simplex virus following intravenous inoculation of mice was defined by in vitro co-cultivation techniques. The virus could be detected in central and peripheral nervous systems (including adrenal medulla), but could not be found in any non-neural tissues. Spinal ganglia were the organs most commonly involved. The relationship of these findings to the natural history of herpetic infections is discussed. Received 30 September 1975; accepted 26 November 1975.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-31-1-75