Aqueous Solubility of 14C‐Triamcinolone Acetonide

The blue tetrazolium colorimetric assay has often been employed in the analysis of corticosteroids. However, the reaction between blue tetrazolium and corticosteroids partly depends on the apparent pH of the system. In an earlier study of the temperature dependence of the solubility and dissolution...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1976-03, Vol.65 (3), p.429-430
Main Authors: Behl, Charanjit Rai, Block, Lawrence H., Borke, Mitchell L.
Format: Article
Language:English
Subjects:
14C-labeled-synthesized
aqueous solubility determined
aqueous-14C-triamcinolone acetonide
Carbon Radioisotopes
Glucocorticoids-14C-triamcinolone acetonide
Glucocorticoids—14C‐triamcinolone acetonide, synthesis, aqueous solubility determined, radioisotopic method
Isotope Labeling
radioisotopic method
Radioisotopic methods-determination of aqueous solubility of 14C-triamcinolone acetonide
Solubility
Solubility, aqueous—14C‐triamcinolone acetonide, radioisotopic method
synthesis
Temperature
Thermodynamics
Triamcinolone acetonide
Triamcinolone Acetonide - analysis
Triamcinolone acetonide, 14C‐labeled—synthesized, aqueous solubility determined, radioisotopic method
Water
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Description
Summary:The blue tetrazolium colorimetric assay has often been employed in the analysis of corticosteroids. However, the reaction between blue tetrazolium and corticosteroids partly depends on the apparent pH of the system. In an earlier study of the temperature dependence of the solubility and dissolution of triamcinolone acetonide in aqueous dissolution media (distilled water and 0.2‐1.0 M potassium chloride solutions), pH was not considered. To determine the reliability of the data previously reported, the solubility of 14C‐triamcinolone acetonide was determined by a radioisotopic method. The results of the analyses, using a liquid scintillation counting system, indicate that the steroid solubility is generally about 20% lower than that reported previously.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600650329