Protection Mechanisms of Non-malignant and Malignant Cells against Ionizing Radiation I. The Cytological Effects of 2-mercaptoethylamine on the Rat and Mouse Ascites Tumors

The present study deals with cytological effects of 2-mercaptoethylamine on the Yoshida-sarcoma, the MTK-sarcoma III and Ehrlich ascites tumor concentrating a special attention on cell growth of tumor. 2-Mercaptoethylamine exerts influence upon tumor cells in process of mitosis, especially on an inc...

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Bibliographic Details
Published in:JOURNAL OF RADIATION RESEARCH 1964, Vol.5 (3/4), p.166-171
Main Authors: Kawamura, F, Kobayashi, J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents
Carcinoma, Ehrlich Tumor
Cell Division - drug effects
Mercaptoethylamines - pharmacology
Mice
Radiation-Protective Agents - pharmacology
Rats
Sarcoma, Experimental
Sarcoma, Yoshida
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Summary:The present study deals with cytological effects of 2-mercaptoethylamine on the Yoshida-sarcoma, the MTK-sarcoma III and Ehrlich ascites tumor concentrating a special attention on cell growth of tumor. 2-Mercaptoethylamine exerts influence upon tumor cells in process of mitosis, especially on an increase of mitotic cells, leading to increase of prophasic cells at first and metaphasic cells secondarily. The protection mechanism against radiation exerted by 2-mercaptoethylamine indicated that this drug induced an increase of mitotic activity. This increase of mitotic activity might be interpreted as a protecting effect against radiation injury.
ISSN:0449-3060
1349-9157
DOI:10.1269/jrr.5.166