Potentiation of the Anti-reserpine Effects of Dihydroxyphenylalanine by Antidepressants and Stimulants

DIHYDROXYPHENYLALANINE (DOPA), the biological precursor of the catecholamines 1 , causes stimulation of the central nervous system in normal mice 2 and mice treated with reserpine 3 . In the latter the effects of DOPA are dramatic; the mice are aroused from the reserpine-induced depression and becom...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1963-08, Vol.199 (4896), p.917-918
Main Authors: MCGRATH, W. R, KETTELER, H. J
Format: Article
Language:English
Subjects:
Amitriptyline
Antidepressive Agents
Central Nervous System Agents
Dextroamphetamine
Dihydroxyphenylalanine
Humanities and Social Sciences
Imipramine
letter
Metabolism
Mice
Monoamine Oxidase Inhibitors
multidisciplinary
Nialamide
Old Medline
Pharmacology
Reserpine
Science
Science (multidisciplinary)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:DIHYDROXYPHENYLALANINE (DOPA), the biological precursor of the catecholamines 1 , causes stimulation of the central nervous system in normal mice 2 and mice treated with reserpine 3 . In the latter the effects of DOPA are dramatic; the mice are aroused from the reserpine-induced depression and become normal or hyperactive in behaviour 3 . Such arousal is thought to be effected through repletion of the reserpine-depleted catecholamines 3
ISSN:0028-0836
1476-4687
DOI:10.1038/199917a0