A twin study of dental dimension. II. Independent genetic determinants

To demonstrate the presence of independent genetic determinants of multiple correlated tooth dimensions from twin data, a multivariate analysis was performed on the covariance matrices of monozygotic and dizygotic within‐pair differences for mesiodistal and buccolingual dimensions of 28 teeth of the...

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Bibliographic Details
Published in:American journal of physical anthropology 1976-05, Vol.44 (3), p.397-412
Main Authors: Potter, Rosario H., Nance, Walter E., Yu, Pao-Lo, Davis, W. Bailey
Format: Article
Language:English
Subjects:
analysis
Correlated measurements
Female
Genetic determinants
Genetic Variation
Genetics, Medical
Humans
Multivariate
Pregnancy
Twins
Twins, Dizygotic
Twins, Monozygotic
Vertical Dimension
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Summary:To demonstrate the presence of independent genetic determinants of multiple correlated tooth dimensions from twin data, a multivariate analysis was performed on the covariance matrices of monozygotic and dizygotic within‐pair differences for mesiodistal and buccolingual dimensions of 28 teeth of the secondary dentition. The results provided strong evidences that the correlation among tooth dimensions is primarily genetic in origin, probably attributable to the pleiotropic action of either independent genes or groups of genes. Among the genetic factors that were identified, one appeared to affect the maxillary teeth in general while a second influenced primarily the anterior mandibular teeth. There was a striking tendency for homologous measurements on the right and left sides to be associated with the same genetic factor. In contrast, genetic determination of the maxillary and mandibular dentition seemed to be independent of each other, and a wider range of genetic factors were found to influence the mandibular than the maxillary teeth, suggesting that a differential degree of evolutionary stability may have been achieved in the teeth of the two jaws.
ISSN:0002-9483
1096-8644
DOI:10.1002/ajpa.1330440304