Response of the Heart to Increased Peripheral Resistance

Changes in the resistance to left ventricular outflow were produced in the anesthetized, open-chest dog by constriction of the descending thoracic aorta, the brachiocephalic artery, or a combination of the two. With constriction of the brachiocephalic artery alone, left ventricular stroke work and p...

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Bibliographic Details
Published in:Circulation research 1963-07, Vol.13 (1), p.33-38
Main Authors: De Mattos, A Darwin, Levy, Matthew N, Zieske, Harrison
Format: Article
Language:English
Subjects:
Animals
Aorta
Aorta, Thoracic
Brachiocephalic Trunk
Carotid Sinus
Catecholamines
Dogs
Heart
Old Medline
Physiology
Reflex
Vascular Resistance
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Summary:Changes in the resistance to left ventricular outflow were produced in the anesthetized, open-chest dog by constriction of the descending thoracic aorta, the brachiocephalic artery, or a combination of the two. With constriction of the brachiocephalic artery alone, left ventricular stroke work and peak power were considerably enhanced, left atrial pressure increased insignificantly, and cardiac output remained constant. With aortic or combined constriction, cardiac output diminished and left atrial pressure rose, but peak power and stroke work did not change significantly. The enhancement of peak power and stroke work by brachiocephalic constriction may be ascribed in part to the supervention of reflex and humoral inotropic mechanisms.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.13.1.33