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Isolation of the Monkey Brain: In vitro Preparation and Maintenance
Sustained viability of the primate brain, as a totally isolated organ preparation, was achieved by utilizing an extracorporeal (compatible donor) circulation. Five rhesus monkey brains, completely isolated neurogenically and vascularly, were perfused in vitro for 30 to 180 minutes. Retention of biol...
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Published in: | Science (American Association for the Advancement of Science) 1963-09, Vol.141 (3585), p.1060-1061 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Sustained viability of the primate brain, as a totally isolated organ preparation, was achieved by utilizing an extracorporeal (compatible donor) circulation. Five rhesus monkey brains, completely isolated neurogenically and vascularly, were perfused in vitro for 30 to 180 minutes. Retention of biological activity was evidenced by: (i) persistent electrocortical activity, and (ii) significant mean A-V$_{O_{2}}$ (5.8 volumes percent) and V-A$_{CO_{2}}$ (5.0 volumes percent) differences across the isolated brain. |
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ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.141.3585.1060 |