Fructose-1,6-bisphosphatase from young and adult rats

Fructose-1,6-bisphosphatase (E.C. 3.1.3.11) was purified from the livers of young (69-86 days) and adult (370-386 days) Fisher rats. The enzyme preparations were examined for increasing amounts of missynthesized proteins by means of heat-inactivation as well as for differences in regulatory properti...

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Bibliographic Details
Published in:Journal of gerontology (Kirkwood) 1976-07, Vol.31 (4), p.409-412
Main Authors: Klefenz, H F, Rockstein, M
Format: Article
Language:English
Subjects:
Aging
Animals
Fructose-Bisphosphatase - physiology
Kinetics
Male
Rats
Online Access:Get full text
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Description
Summary:Fructose-1,6-bisphosphatase (E.C. 3.1.3.11) was purified from the livers of young (69-86 days) and adult (370-386 days) Fisher rats. The enzyme preparations were examined for increasing amounts of missynthesized proteins by means of heat-inactivation as well as for differences in regulatory properties. No significant difference with respect to the fraction of rapidly heat-inactivated enzyme or Km- and Ki-values was found. These results do not support the hypothesis that error accumulation resulting in an error catastrophe is a general phenomenon underlying senescence and death.
ISSN:0022-1422
2331-3323
DOI:10.1093/geronj/31.4.409