Post-traumatic anterior hypopituitarism

Reports of anterior pituitary insufficiency following closed head trauma are unusual. In those cases reported, extensive endocrinologic evidence to support the clinical syndrome is often lacking. The present report documents a case of anterior pituitary insufficiency in a 14-year-old girl following...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1976-06, Vol.57 (6), p.893-896
Main Authors: Paxson, Jr, C L, Brown, D R
Format: Article
Language:English
Subjects:
Adolescent
Craniocerebral Trauma - complications
Female
Humans
Hypopituitarism - etiology
Pituitary Gland, Anterior - physiopathology
Skull Fractures - complications
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Summary:Reports of anterior pituitary insufficiency following closed head trauma are unusual. In those cases reported, extensive endocrinologic evidence to support the clinical syndrome is often lacking. The present report documents a case of anterior pituitary insufficiency in a 14-year-old girl following a skull fracture. Endocrine evaluation one year after her automobile accident revealed hypopituitarism minifested by cachexia, hypothyroidism, hypoadrenocorticism, and hypogonadism with regression of secondary sex characteristics. Laboratory studies demonstrated deficiencies of both trophic and peripheral anterior pituitary hormones. The patient has responded to replacement therapy and is clinically well. A review of previously described cases is included.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.57.6.893