Fixation of Complement to Fragments of Antibody

A specific precipitate of ovalbumin and its rabbit-serum antibody, after fixing human serum complement, was digested with papain. The digest was analyzed immunochemically for complexes of antigen, antibody fragments, and components of complement. The results indicated that complement is not bound to...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1963-08, Vol.141 (3583), p.812-813
Main Authors: Reiss, A. M., Plescia, O. J.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antigen-Antibody Reactions
Antigens
Antiserum
Chromatography
Complement Fixation Tests
Complement System Proteins
Hot Temperature
Humans
Immune Sera
Immunoelectrophoresis
Immunoglobulin fragments
Irradiation
Mice
Old Medline
Ovalbumin
Papain
Precipitates
Rabbits
Skin grafts
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Summary:A specific precipitate of ovalbumin and its rabbit-serum antibody, after fixing human serum complement, was digested with papain. The digest was analyzed immunochemically for complexes of antigen, antibody fragments, and components of complement. The results indicated that complement is not bound to Porter fragment III, but very likely is bound to fragments I and II.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.141.3583.812