Effect of timolol versus propranolol on hypertension and hemodynamics

The effect of timolol versus propranolol on hypertension, hemodynamics, and plasms renin activity was evaluated in 20 men. After two weeks of placebo, 11 men received timolol 30 to 60 mg daily, and nine men received propranolol, 240 to 480 mg daily, for five weeks in a double-blind randomized study....

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1976-07, Vol.54 (1), p.47-51
Main Authors: Aronow, W S, Ferlinz, J, Del Vicario, M, Moorthy, K, King, J, Cassidy, J
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - pharmacology
Adrenergic beta-Antagonists - therapeutic use
Adult
Aged
Blood Urea Nitrogen
Cardiac Catheterization
Clinical Trials as Topic
Creatinine - blood
Heart Rate - drug effects
Humans
Hypertension - drug therapy
Male
Middle Aged
Potassium - blood
Propanolamines - pharmacology
Propanolamines - therapeutic use
Propranolol - pharmacology
Propranolol - therapeutic use
Thiadiazoles - pharmacology
Thiadiazoles - therapeutic use
Vascular Resistance - drug effects
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Summary:The effect of timolol versus propranolol on hypertension, hemodynamics, and plasms renin activity was evaluated in 20 men. After two weeks of placebo, 11 men received timolol 30 to 60 mg daily, and nine men received propranolol, 240 to 480 mg daily, for five weeks in a double-blind randomized study. The 20 men then received placebo again for two weeks. Right heart catheterization was performed in all 20 patients after two weeks of the first placebo and after five weeks of timolol or propranolol. Equipotent doses of timolol and propranolol were equally effective in significantly lowering supine and upright systolic and diastolic blood pressure and heart rate recorded on an outpatient basis. Equipotent doses of timolol and propranolol caused similar hemodynamic effects including similar significant depression of cardiac index. Equipotent doses of timolol and propranolol caused similar marked depression of plasma renin activity. The hypotensive action of timolol and of propranolol was unrelated to their effect on plasma renin activity.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.54.1.47