Intracellular electrophysiological alterations in canine cardiac conducting tissue induced by aprindine and lignocaine

The effects of aprindine and lignocaine (lidocaine USP) were compared on intracellular^ recorded potentials from normal canine conducting tissues. Only aprindine produced marked depression of the maximum rate of rise (Vmax) of action potentials elicited at normal cycle lengths (1000 ms). Both compou...

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Bibliographic Details
Published in:Cardiovascular research 1976-03, Vol.10 (2), p.236-244
Main Authors: STEINBERG, MITCHELL I., GREENSPAN, KALMAN
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Animals
Aprindine - pharmacology
Depression, Chemical
Dogs
Heart Conduction System - drug effects
In Vitro Techniques
Indenes - pharmacology
Kinetics
Lidocaine - pharmacology
Purkinje Fibers - drug effects
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Summary:The effects of aprindine and lignocaine (lidocaine USP) were compared on intracellular^ recorded potentials from normal canine conducting tissues. Only aprindine produced marked depression of the maximum rate of rise (Vmax) of action potentials elicited at normal cycle lengths (1000 ms). Both compounds, however, produced enhanced depression of Vmax at short cycle lengths or at short S1–S2, coupling intervals at normal membrane resting potential. Both lignocaine and aprindine shorten the action potential duration (APD) and effective refractory period (ERP) but increase the ERP/APD ratio. These effects are easily reversible upon perfusion with drug-free solution only in the case of lignocaine.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/10.2.236