Absorption of lithium following administration of slow-release and conventional preparations

The plasma lithium levels of 18 subjects receiving one standard and two slow-release preparations of lithium carbonate were measured at frequent intervals during the 24 hours following oral ingestion of a single dose of the drug. Although the slow-release tablets showed slow-release in vitro, this w...

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Bibliographic Details
Published in:Psychological medicine 1976-02, Vol.6 (1), p.51-58
Main Authors: Tyrer, Stephen, Hullin, R. P., Birch, N. J., Goodwin, J. C.
Format: Article
Language:English
Subjects:
Absorption
Administration, Oral
Adult
Aged
Biological Availability
Delayed-Action Preparations
Drug Evaluation
Feces - analysis
Female
Humans
Lithium - administration & dosage
Lithium - analysis
Lithium - blood
Lithium - metabolism
Male
Middle Aged
Time Factors
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Summary:The plasma lithium levels of 18 subjects receiving one standard and two slow-release preparations of lithium carbonate were measured at frequent intervals during the 24 hours following oral ingestion of a single dose of the drug. Although the slow-release tablets showed slow-release in vitro, this was not so in vivo. One slow-release preparation, in particular, was ineffectively absorbed by some subjects. There was no difference in the rate of absorption and excretion between the other slow-release product and the standard BP preparation. The implications of the results are discussed.
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291700007492