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Absorption of lithium following administration of slow-release and conventional preparations

The plasma lithium levels of 18 subjects receiving one standard and two slow-release preparations of lithium carbonate were measured at frequent intervals during the 24 hours following oral ingestion of a single dose of the drug. Although the slow-release tablets showed slow-release in vitro, this w...

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Published in:	Psychological medicine 1976-02, Vol.6 (1), p.51-58
Main Authors:	Tyrer, Stephen, Hullin, R. P., Birch, N. J., Goodwin, J. C.
Format:	Article
Language:	English
Subjects:	Absorption Administration, Oral Adult Aged Biological Availability Delayed-Action Preparations Drug Evaluation Feces - analysis Female Humans Lithium - administration & dosage Lithium - analysis Lithium - blood Lithium - metabolism Male Middle Aged Time Factors
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creator	Tyrer, Stephen Hullin, R. P. Birch, N. J. Goodwin, J. C.
description	The plasma lithium levels of 18 subjects receiving one standard and two slow-release preparations of lithium carbonate were measured at frequent intervals during the 24 hours following oral ingestion of a single dose of the drug. Although the slow-release tablets showed slow-release in vitro, this was not so in vivo. One slow-release preparation, in particular, was ineffectively absorbed by some subjects. There was no difference in the rate of absorption and excretion between the other slow-release product and the standard BP preparation. The implications of the results are discussed.
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subjects	Absorption Administration, Oral Adult Aged Biological Availability Delayed-Action Preparations Drug Evaluation Feces - analysis Female Humans Lithium - administration & dosage Lithium - analysis Lithium - blood Lithium - metabolism Male Middle Aged Time Factors
title	Absorption of lithium following administration of slow-release and conventional preparations
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