Effect of Lymphocyte Depletion by Thoracic Duct Fistula and Administration of Antilymphocytic Serum on the Survival of Skin Homografts in Rats

SINCE lymphocytes appear to play a crucial part in the homograft reaction it seemed of interest to examine the behaviour of homografts in recipients subjected to chronic lymphocyte depletion by: ( a ) drainage of lymph through a thoracic duct fistula; ( b ) repeated administration of a hetero-specif...

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Bibliographic Details
Published in:Nature (London) 1963-11, Vol.200 (4907), p.702-702
Main Authors: WOODRUFF, M. F. A, ANDERSON, N. A
Format: Article
Language:English
Subjects:
Allografts
Fistula
Humanities and Social Sciences
Immune Sera
letter
Leukopenia
Lymphocyte Depletion
Lymphocytes
multidisciplinary
Old Medline
Rats
Science
Science (multidisciplinary)
Skin Transplantation
Thoracic Duct
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Summary:SINCE lymphocytes appear to play a crucial part in the homograft reaction it seemed of interest to examine the behaviour of homografts in recipients subjected to chronic lymphocyte depletion by: ( a ) drainage of lymph through a thoracic duct fistula; ( b ) repeated administration of a hetero-specific antilymphocytic serum; ( c ) a combination of these procedures.
ISSN:0028-0836
1476-4687
DOI:10.1038/200702a0