Leucocidin from Pseudomonas aeruginosa and membrane functions

Leucocidin from Pseudomonas aeruginosa (strain 158) induced loss of potassium from isolated hepatocytes. The (Na+-K+) stimulated ATPase activity of isolated rat liver plasma membranes showed dose-dependent activation up to 56%. Electron-spin-resonance (ESR) measurements gave no indication of toxin-i...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1976, Vol.293 (1), p.49-55
Main Authors: Hegner, D, Petter, A, Kroker, R, Anwer, M S, Scharmann, W, Breuninger, V
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Adenosine Triphosphatases - metabolism
Animals
Cell Membrane - drug effects
Cell Membrane - enzymology
Cell Membrane - metabolism
Cell Membrane Permeability - drug effects
Female
Guinea Pigs
Heart Conduction System - drug effects
Heart Rate - drug effects
In Vitro Techniques
Leukocidins - pharmacology
Liver - cytology
Male
Muscle Contraction - drug effects
Peripheral Nerves - drug effects
Phospholipids - metabolism
Potassium - metabolism
Pseudomonas aeruginosa
Rats
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Summary:Leucocidin from Pseudomonas aeruginosa (strain 158) induced loss of potassium from isolated hepatocytes. The (Na+-K+) stimulated ATPase activity of isolated rat liver plasma membranes showed dose-dependent activation up to 56%. Electron-spin-resonance (ESR) measurements gave no indication of toxin-induced changes in membrane fluidity. On isolated guinea pig heart auricles the toxin produced an increase in frequency from 180/min to about 300/min, with arrhythmia and transitory flutter. On isolated nerve-diaphragm preparations the toxin caused a contracture and a decline in twitch tension, with a loss of potassium into the bathing solution. The action potential of the electrically stimulated N. ischiadicus of rat or frog was not affected when leucocidin was added to the bathing solution up to a concentration of 10 micrograms/ml.
ISSN:0028-1298
1432-1912
DOI:10.1007/BF00498870