Dopaminergic Agents: Influence on Serotonin in the Molluscan Nervous System

Treatment of the mussel Mytilus edulis with 6-hydroxydopamine or with α-methyl-p-tyrosine decreased dopamine and increased serotonin in the nervous system. Treatment with dopamine decreased serotonin concentrations and prevented the effect of 6-hydroxydopamine. The serotonin concentration appears to...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1976-10, Vol.194 (4264), p.539-541
Main Authors: Stefano, George B., Catapane, Edward, Aiello, Edward
Format: Article
Language:English
Subjects:
Animals
Bivalvia
Dopamine - metabolism
Dopamine - pharmacology
Dopamine agents
Fluorescence
Ganglia
Gills - innervation
Histocytochemistry
Hydroxydopamines - pharmacology
Methyltyrosines - pharmacology
Mussels
Nerves
Neurons
Neurons - metabolism
Neuropil
Physiological regulation
Serotonin receptors
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Summary:Treatment of the mussel Mytilus edulis with 6-hydroxydopamine or with α-methyl-p-tyrosine decreased dopamine and increased serotonin in the nervous system. Treatment with dopamine decreased serotonin concentrations and prevented the effect of 6-hydroxydopamine. The serotonin concentration appears to be determined in part by the concentration of dopamine.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.973139