ORAL RABIES VACCINE: EVALUATION OF ITS INFECTIVITY IN THREE SPECIES OF RODENTS

The safety of oral rabies vaccine was evaluated in 3 species of rodents, ani-mals which might inadvertently consume field-distributed vaccine baits intended for foxes. The potentials for infection from bait ingestion and transmission through cannibalism were evaluated. Results indicate that ingestio...

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Bibliographic Details
Published in:American journal of epidemiology 1976-09, Vol.104 (3), p.294-298
Main Authors: WINKLER, WILLIAM G., SHADDOCK, JOHN H., WILLIAMS, L. W.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
bait
Foxes
Mice
oral
rabies
Rabies - etiology
Rabies - microbiology
Rabies - veterinary
Rabies Vaccines - administration & dosage
Rabies Vaccines - adverse effects
Rabies virus - isolation & purification
Rats
rodent diseases
Rodent Diseases - etiology
Rodent Diseases - microbiology
vaccines
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Summary:The safety of oral rabies vaccine was evaluated in 3 species of rodents, ani-mals which might inadvertently consume field-distributed vaccine baits intended for foxes. The potentials for infection from bait ingestion and transmission through cannibalism were evaluated. Results indicate that ingestion of the vaccine baits used in these experiments will result in infection and disease ofsome rodents. Of 64 rodents which ate baits. 19 (30%) died of clinical rabies; the diagnosis was confirmed in 11 (17%), and 2 (3%) had demonstrable rabies virus in their salivary glands. Only 3 of 112 (3%) rodents that ate vaccine-infected rodents contracted rabies, and none had demonstrable virus in their salivary glands.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a112302