Reduction of Pten dose leads to neoplastic development in multiple organs of Pten (shRNA) mice

To address the impact of partial reduction of Pten on tumor initiation, we generated PtenshRNA mice, in which PTEN expression was reduced below normal levels in various tissues. PtenshRNA mice frequently developed lymphoid and prostatic hyperplasia, splenomegaly, and sebaceous adenomas. Our observat...

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Bibliographic Details
Published in:Cancer biology & therapy 2010-12, Vol.10 (11), p.1194-1200
Main Authors: Shen-Li, Hong, Koujak, Susan, Szablocs, Matthias, Parsons, Ramon
Format: Article
Language:English
Subjects:
Adenoma - enzymology
Adenoma - genetics
Adrenal Glands - pathology
Animals
Brain - anatomy & histology
Brain - enzymology
Endometrium - pathology
Female
Hyperplasia
Lymphatic Diseases - enzymology
Lymphatic Diseases - genetics
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Neoplasms, Experimental - enzymology
Neoplasms, Experimental - genetics
Organ Size
Phosphorylation
Prostatic Hyperplasia - enzymology
Prostatic Hyperplasia - genetics
Prostatic Neoplasms - enzymology
Prostatic Neoplasms - genetics
Proto-Oncogene Proteins c-akt - metabolism
PTEN Phosphohydrolase - biosynthesis
PTEN Phosphohydrolase - deficiency
PTEN Phosphohydrolase - genetics
RNA, Small Interfering - administration & dosage
RNA, Small Interfering - genetics
Sebaceous Gland Neoplasms - enzymology
Sebaceous Gland Neoplasms - genetics
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Summary:To address the impact of partial reduction of Pten on tumor initiation, we generated PtenshRNA mice, in which PTEN expression was reduced below normal levels in various tissues. PtenshRNA mice frequently developed lymphoid and prostatic hyperplasia, splenomegaly, and sebaceous adenomas. Our observations support the notion that partial reduction of the dose of Pten with shRNA is sufficient to induce neoplastic disease in multiple organ systems.
ISSN:1555-8576
DOI:10.4161/cbt.10.11.13814