TGFβ: a sleeping giant awoken by integrins

Transforming growth factor beta (TGFβ) controls numerous cellular responses, including proliferation, differentiation, apoptosis and migration. This cytokine is produced by many different cell types and has been implicated in the pathogenesis of many diseases, ranging from autoimmune disorders and i...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2011, Vol.36 (1), p.47-54
Main Authors: Worthington, John J., Klementowicz, Joanna E., Travis, Mark A.
Format: Article
Language:English
Subjects:
Animals
apoptosis
biochemical mechanisms
cytokines
fibrosis
human health
Humans
infectious diseases
integrins
Integrins - immunology
Integrins - metabolism
pathogenesis
Protein Binding
Signal Transduction
therapeutics
transforming growth factor beta
Transforming Growth Factor beta - chemistry
Transforming Growth Factor beta - immunology
Transforming Growth Factor beta - metabolism
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Summary:Transforming growth factor beta (TGFβ) controls numerous cellular responses, including proliferation, differentiation, apoptosis and migration. This cytokine is produced by many different cell types and has been implicated in the pathogenesis of many diseases, ranging from autoimmune disorders and infectious diseases to fibrosis and cancer. However, TGFβ is always produced as an inactive complex that must be activated to enable binding to its receptor and subsequent function. Recent evidence highlights a crucial role for members of the integrin receptor family in controlling the activation of TGFβ. These pathways are important in human health and disease, and new insights into the biochemical mechanisms that allow integrins to control TGFβ activation could prove useful in the design of therapeutics.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2010.08.002