Formation and Enterohepatic Circulation of Water-soluble Metabolites of Retinol (Vitamin A) in the Rat

BIOLOGICALLY active metabolites of retinoic acid are apparently formed in the stomach 1 and colon 2 , and water-soluble metabolites of retinol or retinoic acid appear in the plasma, urine, and fæces of chickens and rats within 24 h after administration 3–6 . The organs involved in these transformati...

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Bibliographic Details
Published in:Nature (London) 1964-03, Vol.201 (4925), p.1222-1223
Main Authors: ZACHMAN, RICHARD D, OLSON, JAMES ALLEN
Format: Article
Language:English
Subjects:
Bile
Carbon Isotopes
Chromatography
Duodenum
Enterohepatic Circulation
Humanities and Social Sciences
letter
Liver - physiology
Metabolism
multidisciplinary
Old Medline
Perfusion
Rats
Science
Science (multidisciplinary)
Vitamin A
Water
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Summary:BIOLOGICALLY active metabolites of retinoic acid are apparently formed in the stomach 1 and colon 2 , and water-soluble metabolites of retinol or retinoic acid appear in the plasma, urine, and fæces of chickens and rats within 24 h after administration 3–6 . The organs involved in these transformations, the chemical nature of the products, and the route of excretion have not been defined in detail. This report concerns the conversion in rat liver of 14 C-retinol and 14 C-retinoic acid to water-soluble metabolites, which are afterwards excreted in the bile, are largely absorbed from the gut, and are re-excreted in the bile. Preliminary observations on the properties of these metabolites are presented.
ISSN:0028-0836
1476-4687
DOI:10.1038/2011222a0