Synthesis and Antibacterial and Antifungal Activities of Alkyl and Polyhalophenyl Esters of Benzo[b]‐3‐Methyl‐2‐Furancarbamic Acid

Several alkyl and polyhalophenyl esters of benzo[b]‐3‐methyl‐2‐furancarbamic acid were prepared and tested for anti‐fungal activity against Candida albicans, Penicillium notatum, and Aspergillus niger. The pentachlorophenyl ester was the most active substance and the only compound to show antibacter...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1976-07, Vol.65 (7), p.1085-1087
Main Authors: Ghabgharan, F., Kooshkabadi, H., Emami, M., Rashidbaigi, A., Shafiee, A.
Format: Article
Language:English
Subjects:
Antibacterial activity-alkyl and polyhalophenyl esters of furancarbamic acid synthesized and screened
Antifungal activity-alkyl and polyhalophenyl esters of furancarbamic acid synthesized and screened
Bacteria - drug effects
Benzofurans - chemical synthesis
Benzofurans - pharmacology
Carbamates - chemical synthesis
Carbamic acid esters-synthesized
Carbamic acid esters—synthesized, screened for antifungal and antibacterial activities
Fungi - drug effects
Furancarbamic acid esters-synthesized
Furancarbamic acid esters—synthesized, screened for antifungal and antibacterial activities
screened for antifungal and antibacterial activities
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Summary:Several alkyl and polyhalophenyl esters of benzo[b]‐3‐methyl‐2‐furancarbamic acid were prepared and tested for anti‐fungal activity against Candida albicans, Penicillium notatum, and Aspergillus niger. The pentachlorophenyl ester was the most active substance and the only compound to show antibacterial activity against Staphylococcus aureus.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600650737