Polypeptide Chains of Human Gamma-Globulin: Cellular Localization by Fluorescent Antibody

Fluorescent antibody to antigenically distinct portions of 7S gammaglobulin was used to study the occurrence of H-chains and L-chains of types I and II within single cells. Individual lymphoid cells contained both H- and L-chains, but individual cells did not contain both antigenic types of L-chains...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1964-06, Vol.144 (3626), p.1590-1591
Main Authors: Bernier, George M., Cebra, John J.
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Antiserum
Bence Jones Protein
Fluorescent Antibody Technique
gamma-Globulins
Globulins
Humans
Immune Sera
Immunoglobulins
Immunologic Tests
Lymph
Lymphoid Tissue
Molecules
Old Medline
Peptides
Specimens
Spleen
Tactile information
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Summary:Fluorescent antibody to antigenically distinct portions of 7S gammaglobulin was used to study the occurrence of H-chains and L-chains of types I and II within single cells. Individual lymphoid cells contained both H- and L-chains, but individual cells did not contain both antigenic types of L-chains.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.144.3626.1590