Tobramycin Therapy of Infections Due to Pseudomonas aeruginosa in Patients with Cystic Fibrosis: Effect of Dosage and Concentration of Antibiotic in Sputum

Established respiratory infections with mucoid Pseudomonas aeruginosa in patients suffermg from cystic fibrosis were treated with conventional as well as larger doses of tobramycin. The infection was eradicated in four of the 17 patients treated, but the duration of follow-up study of one patient wa...

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Bibliographic Details
Published in:The Journal of infectious diseases 1976-08, Vol.134 (Supplement-1), p.S191-S193
Main Authors: McCrae, W. Morrice, Raeburn, J. A., Hanson, E. J.
Format: Article
Language:English
Subjects:
Adolescent
Anti-Bacterial Agents - therapeutic use
Antibiotics
Child
Child, Preschool
Clinical Studies: Other Infections
Cystic fibrosis
Cystic Fibrosis - complications
Dosage
Erythrocyte sedimentation rate
Follow up studies
Humans
Infant
Infections
Pseudomonas
Pseudomonas aeruginosa
Pseudomonas Infections - complications
Pseudomonas Infections - drug therapy
Side effects
Sputum
Sputum - metabolism
Tobramycin - administration & dosage
Tobramycin - metabolism
Tobramycin - therapeutic use
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Summary:Established respiratory infections with mucoid Pseudomonas aeruginosa in patients suffermg from cystic fibrosis were treated with conventional as well as larger doses of tobramycin. The infection was eradicated in four of the 17 patients treated, but the duration of follow-up study of one patient was short. It appeared that treatment was most successful in those patients in whom the highest peak concentrations of tobramycin in sputum were obtained. No side effects were noted, even when tobramycin was given in large doses for two weeks.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/134.Supplement_1.S191