Pulmonary Alveolar Cell Inclusions: Their Development in the Rat

Cytoplasmic inclusions in the special pulmonary alveolar cells of adult, newborn, and fetal rats were investigated by electron microscopy and histochemistry, and lung extracts were analyzed for surface-tension activity. The inclusions were positive in the periodic acid-Schiff test after digestion wi...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1964-09, Vol.145 (3637), p.1192-1193
Main Authors: Buckingham, Sue, McNary, William F., Sommers, Sheldon C.
Format: Article
Language:English
Subjects:
Adenoviruses
Alkaline Phosphatase
Animals
Animals, Newborn
Cell Differentiation
Coloring Agents
Cytoplasmic inclusions
Electrons
Fetus
Histocytochemistry
Inclusion Bodies
Lung
Lungs
Microscopy
Microscopy, Electron
Mitochondria
Old Medline
Particle density
Pathology
Pulmonary alveoli
Rats
Tumors
Viruses
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Description
Summary:Cytoplasmic inclusions in the special pulmonary alveolar cells of adult, newborn, and fetal rats were investigated by electron microscopy and histochemistry, and lung extracts were analyzed for surface-tension activity. The inclusions were positive in the periodic acid-Schiff test after digestion with diastase and were not stained with toluidine blue; they formed myelin figures and possessed alkaline phosphatase activity. Both the typical surface tension activity and the inclusions developed 2 days before birth. These properties differentiated the inclusions from mitochondria.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.145.3637.1192