Cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in normal and chronic lymphocytic leukemia lymphocytes

The specific activity of cyclic adenosine 3':5'-monophosphate phosphodiesterase was measured in lymphocytes isolated from the blood of normal subjects, from patients with chronic lymphocytic leukemia, and from tonsil tissue. The mean specific activity of cyclic adenosine 3':5'-mo...

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Published in:Cancer research (Chicago, Ill.) Ill.), 1976-11, Vol.36 (11 Pt 1), p.3958-3962
Main Authors: Scher, N S, Quagliata, F, Malathi, V G, Faig, D, Melton, R A, Silber, R
Format: Article
Language:English
Subjects:
3',5'-Cyclic-AMP Phosphodiesterases - blood
B-Lymphocytes - enzymology
Humans
Leukemia, Lymphoid - enzymology
Leukocyte Count
Lymphocytes - enzymology
Phosphoric Diester Hydrolases - blood
T-Lymphocytes - enzymology
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container_end_page 3962
container_issue 11 Pt 1
container_start_page 3958
container_title Cancer research (Chicago, Ill.)
container_volume 36
creator Scher, N S
Quagliata, F
Malathi, V G
Faig, D
Melton, R A
Silber, R
description The specific activity of cyclic adenosine 3':5'-monophosphate phosphodiesterase was measured in lymphocytes isolated from the blood of normal subjects, from patients with chronic lymphocytic leukemia, and from tonsil tissue. The mean specific activity of cyclic adenosine 3':5'-monophosphate phosphodiesterase in the lymphocytes from patients with untreated chronic lymphocytic leukemia was lower than that in lymphocytes from the blood of normal subjects or from tonsils. Cyclic adenosine 3':5'-monophosphate phosphodiesterase levels did not correlate with differences in B- and T-cell lymphocyte subpopulations or with peripheral blood lymphocyte counts.
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subjects 3',5'-Cyclic-AMP Phosphodiesterases - blood
B-Lymphocytes - enzymology
Humans
Leukemia, Lymphoid - enzymology
Leukocyte Count
Lymphocytes - enzymology
Phosphoric Diester Hydrolases - blood
T-Lymphocytes - enzymology
title Cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in normal and chronic lymphocytic leukemia lymphocytes
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