Negative Inotropic Effect of the Vagus Nerves upon the Canine Ventricle

In an innervated, paced, left heart preparation in which the left ventricle contracted against a constant volume of incompressible fluid (isovolumetric preparation), electrical stimulation of the distal end of either sectioned cervical vagus nerve decreased the peak tension generated by the left ven...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1964-06, Vol.144 (3623), p.1223-1225
Main Authors: DeGeest, Hilaire, Levy, Matthew N., Zieske, Harrison
Format: Article
Language:English
Subjects:
Animals
Blood Pressure
Calcium
Dogs
Dosage
Electric Stimulation
Heart
Heart Rate
Heart Ventricles
Monoamine oxidase inhibitors
Nerves
Old Medline
Oxidases
Phosphates
Physiology
Sodium
Systolic pressure
Vagus Nerve
Ventricular pressure
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Summary:In an innervated, paced, left heart preparation in which the left ventricle contracted against a constant volume of incompressible fluid (isovolumetric preparation), electrical stimulation of the distal end of either sectioned cervical vagus nerve decreased the peak tension generated by the left ventricle. The vagi, therefore, exert a negative inotropic effect directly upon the ventricular myocardium.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.144.3623.1223