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Negative Inotropic Effect of the Vagus Nerves upon the Canine Ventricle

In an innervated, paced, left heart preparation in which the left ventricle contracted against a constant volume of incompressible fluid (isovolumetric preparation), electrical stimulation of the distal end of either sectioned cervical vagus nerve decreased the peak tension generated by the left ven...

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Published in:	Science (American Association for the Advancement of Science) 1964-06, Vol.144 (3623), p.1223-1225
Main Authors:	DeGeest, Hilaire, Levy, Matthew N., Zieske, Harrison
Format:	Article
Language:	English
Subjects:	Animals Blood Pressure Calcium Dogs Dosage Electric Stimulation Heart Heart Rate Heart Ventricles Monoamine oxidase inhibitors Nerves Old Medline Oxidases Phosphates Physiology Sodium Systolic pressure Vagus Nerve Ventricular pressure
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description	In an innervated, paced, left heart preparation in which the left ventricle contracted against a constant volume of incompressible fluid (isovolumetric preparation), electrical stimulation of the distal end of either sectioned cervical vagus nerve decreased the peak tension generated by the left ventricle. The vagi, therefore, exert a negative inotropic effect directly upon the ventricular myocardium.
doi_str_mv	10.1126/science.144.3623.1223
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source	American Association for the Advancement of Science
subjects	Animals Blood Pressure Calcium Dogs Dosage Electric Stimulation Heart Heart Rate Heart Ventricles Monoamine oxidase inhibitors Nerves Old Medline Oxidases Phosphates Physiology Sodium Systolic pressure Vagus Nerve Ventricular pressure
title	Negative Inotropic Effect of the Vagus Nerves upon the Canine Ventricle
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