Evaluation of Polymeric Materials I.: Screening of Selected Polymers as Film Coating Agents

A procedure has been developed for the systematic evaluation of mechanical, thermal, and stability properties of polymeric materials through the study of unsupported films. Films of selected vinyl, acrylic, and cellulosic polymers were prepared by the knife edge applicator method and the mercury sub...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1964-04, Vol.53 (4), p.395-401
Main Authors: Munden, Bill J., George Dekay, H., Banker, Gilbert S.
Format: Article
Language:English
Subjects:
Chemistry, Pharmaceutical
Old Medline
Pharmacy
Polymers
Tablets
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Summary:A procedure has been developed for the systematic evaluation of mechanical, thermal, and stability properties of polymeric materials through the study of unsupported films. Films of selected vinyl, acrylic, and cellulosic polymers were prepared by the knife edge applicator method and the mercury substrate technique. The mercury substrate technique afforded superior control of film thickness and facilitated film removal. Films that were very permeable to water vapor were rather impermeable to oxygen and vice versa. This relationship is discussed as it relates to a combination of the hydrophilic-lipophilic and pore theories of film structure. The unsupported vinyl films possessed superior mechanical properties of those tested. Moisture absorption by the polymer films was negligible. There was no discernible decomposition according to infrared analysis of the films, due to thermal, photo-oxidation, and/or aging effects.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600530411