PRENATAL NARROWING OR CLOSURE OF THE FORAMEN OVALE

In the current study cases are presented in which a prenatally narrowed or closed foramen ovale was associated with left heart chambers of normal or near-normal size. Such infants develop an increased pulmonary arterial muscle mass with hypertrophy and dilation of the right cardiac chambers during f...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1964-11, Vol.30 (5), p.736-742
Main Authors: NAEYE, R L, BLANC, W A
Format: Article
Language:English
Subjects:
Fetal Death
Foramen Ovale
Heart Atria
Heart Septal Defects
Heart Septal Defects, Atrial
Humans
Infant
Infant Mortality
Infant, Newborn
Old Medline
Pathology
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Summary:In the current study cases are presented in which a prenatally narrowed or closed foramen ovale was associated with left heart chambers of normal or near-normal size. Such infants develop an increased pulmonary arterial muscle mass with hypertrophy and dilation of the right cardiac chambers during fetal life. Much of the arterial muscle mass persists after birth and may well be responsible for the early neonatal death of the infants. The longer asymptomatic survival of one infant suggests that therapy may be possible.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.30.5.736