SEMISYNTHETIC β-LACTAM ANTIBIOTICS. 8: STRUCTURE-ACTIVITY RELATIONSHIPS OF α-SULFOCEPHALOSPORINS

Synthesis and in vitro activity of a number of cephalosporins having α-sulfoacyl- or other acyl groups, e.g., α-carboxyacyl- and α-sulfoaminoacyl- at the 7-position and bearing a variety of heterocyclic thioether or pyridinium moieties at the 3-position are described.

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Bibliographic Details
Published in:Journal of antibiotics 1976, Vol.29(9), pp.928-936
Main Authors: NOMURA, HIROAKI, MINAMI, ISAO, HITAKA, TAKENORI, FUGONO, TAKESHI
Format: Article
Language:English
Subjects:
Bacteria - drug effects
Cephalosporins - analysis
Cephalosporins - pharmacology
Structure-Activity Relationship
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Description
Summary:Synthesis and in vitro activity of a number of cephalosporins having α-sulfoacyl- or other acyl groups, e.g., α-carboxyacyl- and α-sulfoaminoacyl- at the 7-position and bearing a variety of heterocyclic thioether or pyridinium moieties at the 3-position are described.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.29.928