Reduction by Hyperbaric Oxygenation of the Mortality from Ventricular Fibrillation Following Coronary Artery Ligation

The effect of the inhalation of hyperbaric oxygen on the incidence of ventricular fibrillation following ligation of the circumflex coronary artery was studied in 151 dogs weighing 17 kg or more.Fifty-two per cent of the animals in the control group (room air, 1 atm abs) survived the challenge of th...

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Bibliographic Details
Published in:Circulation research 1964-12, Vol.15 (6), p.497-502
Main Authors: Chardack, William M, Gage, Andrew A, Federico, Anthony J, Cusick, John K, Matsumoto, Paul J. h, Lanphier, Edward H
Format: Article
Language:English
Subjects:
Animals
Arteries
Body Weight
Cardiovascular System
Coronary Vessels
Dogs
Heart
Hyperbaric Oxygenation
Ligation
Mortality
Old Medline
Physiology
Ventricular Fibrillation
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Summary:The effect of the inhalation of hyperbaric oxygen on the incidence of ventricular fibrillation following ligation of the circumflex coronary artery was studied in 151 dogs weighing 17 kg or more.Fifty-two per cent of the animals in the control group (room air, 1 atm abs) survived the challenge of this ligation. Survival increased to 60.4, 70, and 77.8% in the groups given 100% oxygen at an ambient pressure of 1, 2, and 4 atm abs, respectively. The orderly progression in the proportion of survivals is impressive but only approaches statistical significance.The results of these experiments are less dramatic than those previously reported by others. They do point out the need for cautious clinical trial in rigidly controlled series.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.15.6.497