Adenylate cyclase of the dog gastric mucosa: stimulation by histamine and inhibition by metiamide

The activity of the non-stimulated, basal adenylate cyclase of the dog gastric mucosa is reduced by the histamine H2-receptor antagonist metiamide but not by the histamine H1-receptor antagonist mepyramine. Histamine activates the adenylate cyclase only slightly. In the presence of 10(-5) M metiamid...

Full description

Saved in:
Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1976-08, Vol.294 (2), p.207-208
Main Authors: Ruoff, H.J, Sewing, K.F
Format: Article
Language:English
Subjects:
Adenylyl Cyclases - metabolism
animal science
Animals
Dogs
Female
Gastric Mucosa - enzymology
Histamine - pharmacology
In Vitro Techniques
livestock
Metiamide - pharmacology
Pyrilamine - pharmacology
Thiourea - analogs & derivatives
zoology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The activity of the non-stimulated, basal adenylate cyclase of the dog gastric mucosa is reduced by the histamine H2-receptor antagonist metiamide but not by the histamine H1-receptor antagonist mepyramine. Histamine activates the adenylate cyclase only slightly. In the presence of 10(-5) M metiamide a concentration-dependent stimulation of the enzyme by histamine was found. These data indicate that endogenous histamine in dog gastric mucosal homogenate is contributing at least in part to what is measured as "basal" adenylate cyclase activity. This effect is mediated by H2-receptor excitation and in earlier studies has prevented the demonstration of a stimulatory effect of exogenous histamine on this enzyme.
ISSN:0028-1298
1432-1912
DOI:10.1007/BF00507855