Liposome-induced morphological differentiation of murine neuroblastoma

LIQUID crystals made of lipids (liposomes), initially devised as models of biological membranes 1–4 , have more recently been used as artificial carriers because of their ability to bind and fuse with biological membranes and discharge their soluble content into the cytoplasm 5–7 . Preliminary studi...

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Bibliographic Details
Published in:Nature (London) 1976-10, Vol.263 (5578), p.604-606
Main Authors: CHEN, J. S, DEL FA, A, DI LUZIO, A, CALISSANO, P
Format: Article
Language:English
Subjects:
Binding Sites
Cell Differentiation - drug effects
Cell Division - drug effects
Cell Line
Humanities and Social Sciences
letter
Liposomes - pharmacology
Microtubules - ultrastructure
multidisciplinary
Neuroblastoma - pathology
Neurons - cytology
Neurons - ultrastructure
Phosphatidylcholines
Phosphatidylserines
Science
Science (multidisciplinary)
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Summary:LIQUID crystals made of lipids (liposomes), initially devised as models of biological membranes 1–4 , have more recently been used as artificial carriers because of their ability to bind and fuse with biological membranes and discharge their soluble content into the cytoplasm 5–7 . Preliminary studies in our laboratory have shown that lisopsomes loaded with the nerve growth factor (NGF) induce morphological differentiation in a murine neuroblastoma cell line which does not exhibit morphological changes on addition of NGF to the culture medium. Control experiments with liposomes in absence of NGF however, also resulted in process formation in neuroblastoma (NB) cells. Our attention was therefore focused on the effect of the carrier itself, rather than on the agent carried.
ISSN:0028-0836
1476-4687
DOI:10.1038/263604a0