Enhancement Of Dissolution Rates Of Poorly Water‐Soluble Drugs By Crystallization In Aqueous Surfactant Solutions I: Sulfathiazole, Prednisone, And Chloramphenicol

Effects of crystallization of poorly water‐soluble drugs in aqueous surfactant solutions on in vitro dissolution rates were investigated. Marked enhancement was observed for chloramphenicol, sulfathiazole, and prednisone. Differential thermal analysis studies indicated the presence of small amounts...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1976-11, Vol.65 (11), p.1702-1704
Main Authors: Chiou, Win L., Chen, Shaw‐Jen, Athanikar, Narayan
Format: Article
Language:English
Subjects:
and prednisone in polysorbate 80
aqueous-crystallization of chloramphenicol
Chemistry, Pharmaceutical
Chloramphenicol
Chloramphenicol-dissolution rate
Chloramphenicol—dissolution rate, effect of crystallization in aqueous surfactant solutions
Crystallization
Dissolution rates-chloramphenicol
Dissolution rates—chloramphenicol, sulfathiazole, prednisone, effect of crystallization in aqueous surfactant solutions
effect of crystallization in aqueous surfactant solutions
effect on dissolution rates
Polysorbates - pharmacology
Prednisone
Prednisone-dissolution rate
Prednisone—dissolution rate, effect of crystallization in aqueous surfactant solutions
Solubility
sulfathiazole
Sulfathiazole-dissolution rate
Sulfathiazoles
Sulfathiazole—dissolution rate, effect of crystallization in aqueous surfactant solutions
Surface-Active Agents - pharmacology
Surfactants
Surfactants, aqueous—crystallization of chloramphenicol, sulfathiazole, and prednisone in polysorbate 80, effect on dissolution rates
Thermography
Time Factors
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Summary:Effects of crystallization of poorly water‐soluble drugs in aqueous surfactant solutions on in vitro dissolution rates were investigated. Marked enhancement was observed for chloramphenicol, sulfathiazole, and prednisone. Differential thermal analysis studies indicated the presence of small amounts of surfactant in surfactant‐treated crystals. Possible mechanisms of dissolution enhancement are discussed.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600651137