Inhibition of catecholamine biosynthesis and memory processes

Rats injected with 60 mg/kg of alpha-methyl tyrosine (alpha-MT) immediately after a training in a shuttle box impaired retention of conditioned avoidance response (CAR). DL-Dopa (200 mg/kg) administered 5, 30, 60, and 120 min after alpha-MT treatment counteracted the depressive effect of this drug d...

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Bibliographic Details
Published in:Psychopharmacology 1976-01, Vol.51 (1), p.65-69
Main Authors: Fulginiti, S, Molina, V A, Orsingher, O A
Format: Article
Language:English
Subjects:
Animals
Avoidance Learning
Catecholamines - physiology
Conditioning (Psychology)
Dihydroxyphenylalanine - pharmacology
Ditiocarb - pharmacology
Dopamine - physiology
Female
Male
Memory - physiology
Methyltyrosines - pharmacology
Norepinephrine - physiology
Rats
Retention (Psychology) - drug effects
Retention (Psychology) - physiology
Time Factors
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Summary:Rats injected with 60 mg/kg of alpha-methyl tyrosine (alpha-MT) immediately after a training in a shuttle box impaired retention of conditioned avoidance response (CAR). DL-Dopa (200 mg/kg) administered 5, 30, 60, and 120 min after alpha-MT treatment counteracted the depressive effect of this drug during the retention test; at longer times it was ineffective. Post-trial injections of 600 mg/kg of diethyldithiocarbamate (DDC) impaired retention of CAR; at a lower dose (300 mg/kg) it had no effect. Administration of alpha-MT (60 mg/kg) immediately after passive avoidance training lowered memory in females but not in males. These results suggest that noradrenaline (NA) is required for memory consolidation processes for about 2 h after training.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00426323