A COMPARISON OF SOME CARDIORESPIRATORY EFFECTS OF ALTHESIN AND KETAMINE WHEN USED FOR INDUCTION OF ANAESTHESIA IN PATIENTS WITH CARDIAC DISEASE

Cardiorespiratory effects of ketamine and Althesin were measured in two groups of premedicated patients with cardiac disease. The drugs were given in clinically equivalent doses with a second dose administered about 10 min after induction. The first dose of ketamine caused a marked increase in syste...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1976-11, Vol.48 (11), p.1071-1081
Main Authors: SAVEGE, T.M., COLVIIN, M.P., WEAVER, E.J.M., BOND, C., DRAKE, J., INNISS, R.
Format: Article
Language:English
Subjects:
Alfaxalone Alfadolone Mixture - pharmacology
Anesthesia, Intravenous
Blood Pressure - drug effects
Carbon Dioxide - blood
Cardiac Output - drug effects
Central Venous Pressure - drug effects
Female
Heart Diseases - physiopathology
Heart Rate - drug effects
Hemodynamics - drug effects
Humans
Ketamine - pharmacology
Male
Middle Aged
Oxygen - blood
Pregnanediones - pharmacology
Respiration - drug effects
Space life sciences
Vascular Resistance - drug effects
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Summary:Cardiorespiratory effects of ketamine and Althesin were measured in two groups of premedicated patients with cardiac disease. The drugs were given in clinically equivalent doses with a second dose administered about 10 min after induction. The first dose of ketamine caused a marked increase in systemic and pulmonary arterial pressure, heart rate, and central venous and wedge pressures and cardiac index. The first dose of Althesin caused a decrease in systemic arterial pressure, central venous pressure, cardiac index and heart work, but little change in heart rate. The second dose of induction agent was administered before the cardiorespiratory effects of the initial dose had resolved. The second dose of Althesin caused changes similar to thosefollowing the first dose, but less marked. The changes following the second dose of ketamine were opposite to those following the first dose.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/48.11.1071