Non-polar urinary metabolites of chlorpromazine in male schizophrenics

Twenty-four hour urine collections were made on 12 male schizophrenic patients recieving varying doses of chlorpromazine. Gas chromatographic analyses for chlorpromazine and six non-polar metabolites were performed. Two major metabolites, desdimethylchlorpromazine sulfoxide (nor 2CPSO) and desmethyl...

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Bibliographic Details
Published in:Journal of psychiatric research 1964-12, Vol.2 (4), p.299-305
Main Authors: Rose, R.M., DiMascio, A., Klerman, G.L.
Format: Article
Language:English
Subjects:
Biological Transport
Chlorpromazine
Chromatography
Drug Therapy
Fluids and Secretions
Humans
Metabolism
Old Medline
Schizophrenia
Urine
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Summary:Twenty-four hour urine collections were made on 12 male schizophrenic patients recieving varying doses of chlorpromazine. Gas chromatographic analyses for chlorpromazine and six non-polar metabolites were performed. Two major metabolites, desdimethylchlorpromazine sulfoxide (nor 2CPSO) and desmethylchlorpromazine sulfoxide (nor 1CPSO) were found to be excreted in significant amounts, accounting for about 7 per cent of the ingested dose. The variations in excretion of these compounds were found to be independent of urine volume, dose administered, or of the clinical state of the patients. It was concluded that the metabolism of chlorpromazine into the oxidized demethylated forms was a relatively constant phenomenon.
ISSN:0022-3956
1879-1379
DOI:10.1016/0022-3956(64)90015-9