Histoplasmosis in purebred mice: influence of genetic susceptibility and immune depression on treatment

These experiments demonstrate that susceptibility to Histoplasma infection of the mouse is dramatically influenced by genetic and immunologic factors, and that these factors appear to exert little influence on response to therapy. They further demonstrate that such influence may vary in different vi...

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Bibliographic Details
Published in:Mycopathologia (1975) 1976-01, Vol.60 (1), p.39-43
Main Authors: Patton, R M, Riggs, A R, Compton, S B, Chick, E W
Format: Article
Language:English
Subjects:
Amphotericin B - therapeutic use
Animals
Antilymphocyte Serum - adverse effects
Female
Histoplasma - isolation & purification
Histoplasma - pathogenicity
Histoplasmosis - drug therapy
Histoplasmosis - genetics
Histoplasmosis - immunology
Histoplasmosis - mortality
Immunosuppression
Liver - microbiology
Lung - microbiology
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Species Specificity
Spleen - microbiology
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Description
Summary:These experiments demonstrate that susceptibility to Histoplasma infection of the mouse is dramatically influenced by genetic and immunologic factors, and that these factors appear to exert little influence on response to therapy. They further demonstrate that such influence may vary in different visceral organs. The explanation for these observations remains to be elucidated.
ISSN:0301-486X
1573-0832
DOI:10.1007/BF00442546