Simultaneous Determination of 4-Nitroanisole, 4-Nitrophenol and 4-Nitrocatechol by Phase-Sensitive ac Polarography

Phase‐sensitive ac polarography was applied to the simultaneous quantitative determination of 4‐nitroanisole, 4‐nitrophenol and 4‐nitrocatechol in alkaline solutions. Certain experimental precautions are necessary to determine each compound in the presence of the other two. Thus, 4‐nitrocatechol is...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1977-01, Vol.66 (1), p.60-63
Main Authors: Burgschat, H., Netter, K.J.
Format: Article
Language:English
Subjects:
4-nitroanisole and 4-nitrocatechol
4-Nitroanisole-polarographic analysis in presence of 4-nitrophenol and 4-nitrocatechol
4-Nitrocatechol-polarographic analysis in presence of 4-nitroanisole and 4-nitrocatechol
4-nitrophenol
4‐Nitroanisole—polarographic analysis in presence of 4‐nitrophenol and 4‐nitrocatechol, alkaline solutions D 4‐Nitrophenol—polarographic analysis in presence of 4‐nitroanisole and 4‐nitrocatechol, alkaline solutions
4‐Nitrocatechol—polarographic analysis in presence of 4‐nitroanisole and 4‐nitrocatechol, alkaline solutions
alkaline solutions
alkaline solutions D 4-Nitrophenol-polarographic analysis in presence of 4-nitroanisole and 4-nitrocatechol
Anisoles - analysis
Catechols - analysis
Copper
Hydrogen-Ion Concentration
Magnesium
Methods
Nitro Compounds - analysis
Nitrophenols - analysis
Polarography
Polarography-simultaneous analyses
Polarography—simultaneous analyses, 4‐nitrophenol, 4‐nitroanisole and 4‐nitrocatechol, alkaline solutions
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Summary:Phase‐sensitive ac polarography was applied to the simultaneous quantitative determination of 4‐nitroanisole, 4‐nitrophenol and 4‐nitrocatechol in alkaline solutions. Certain experimental precautions are necessary to determine each compound in the presence of the other two. Thus, 4‐nitrocatechol is determined indirectly by forming a yellow ratio chelate with cupric ions, whereas 4‐nitroanisole is determined directly by the reduction waves of the nitro group. For the determination of 4‐nitrophenol, the interference by the simultaneously present 4‐nitrocatechol must be eliminated by masking it by the addition of magnesium ions. The method described permits a qualitative and quantitative analysis of all three compounds in one solution since linear calibration curves are obtained.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600660114