Determination of Hyoscyamine Hydrobromide in a Multicomponent Tablet

The quantitative assay of hyoscyamine hydrobromide in a multicomponent tablet formulation is described. The method consists of tablet treatment with sulfuric acid, an ether extraction from an alkaline aqueous solution, followed by quantitative column chromatography to separate the alkaloid from the...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1964-10, Vol.53 (10), p.1257-1258
Main Authors: Beck, Elliot B., Penner, Melvin H., Talmage, Joseph M.
Format: Article
Language:English
Subjects:
Atropa belladonna
Chemistry, Pharmaceutical
Chromatography
Hyoscyamine
Old Medline
Parasympatholytics
Pharmacy
Tablets
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Description
Summary:The quantitative assay of hyoscyamine hydrobromide in a multicomponent tablet formulation is described. The method consists of tablet treatment with sulfuric acid, an ether extraction from an alkaline aqueous solution, followed by quantitative column chromatography to separate the alkaloid from the nonalkaloidal tablet components.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600531032