Persistent Infection with Bovine Herpesvirus-1 (Infectious Bovine Rhinotracheitis Virus) in Cultured Hamster Cells

Bovine herpesvirus-1 infection in hamster embryo cells was found to be dependent upon input multiplicity; productive infection was achieved at input multiplicities greater than one, while persistent infection was established when input multiplicities were about 0.5. This persistence was characterize...

Full description

Saved in:
Bibliographic Details
Published in:In Vitro 1976-10, Vol.12 (10), p.682-686
Main Authors: Michalski, F. J., Hsiung, G. D.
Format: Article
Language:English
Subjects:
Animals
Cell culture techniques
Cell growth
Cell lines
Cricetinae
Culture Techniques
Cultured cells
Cytopathogenic Effect, Viral
Embryonic cells
Fibroblasts
Herpesviridae
Herpesvirus 1, Bovine - growth & development
Herpesvirus 1, Bovine - isolation & purification
Infections
L cells
Mesocricetus
Ungulates
Virus Replication
Viruses
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c177t-8144abb64997b08dcccd5c3e9d928cfb7a5bf1e40850961253272e555f8d4df73
container_end_page 686
container_issue 10
container_start_page 682
container_title In Vitro
container_volume 12
creator Michalski, F. J.
Hsiung, G. D.
description Bovine herpesvirus-1 infection in hamster embryo cells was found to be dependent upon input multiplicity; productive infection was achieved at input multiplicities greater than one, while persistent infection was established when input multiplicities were about 0.5. This persistence was characterized by a noncyclic, minimal degree of cytopathic effect with a low level of released virus. Maintenance of the persistently infected cultures did not require external supportive measures. Subcultivation of the persistently infected cultures led to virus replication followed by CPE and then cell regrowth. Within 3 to 4 weeks after subcultivation a persistent infection was re-established. The possible mechanism for the bovine herpesvirus persistence in hamster cells is discussed.
doi_str_mv 10.1007/BF02797471
format article
fullrecord <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_83728082</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>20170363</jstor_id><sourcerecordid>20170363</sourcerecordid><originalsourceid>FETCH-LOGICAL-c177t-8144abb64997b08dcccd5c3e9d928cfb7a5bf1e40850961253272e555f8d4df73</originalsourceid><addsrcrecordid>eNpFkEtLw0AUhQfxVasb1wqzEhWi88hkJksbrC0UFFG3IZnc0JE86syk4r83ta1d3cX3ce7hIHROyR0lRN6PxoTJWIaS7qEBDaUIWKTifTToIQ9EJMQxOnHukxBOIkaP0CGNCY3CAbIvYJ1xHhqPp00J2pu2wd_Gz_GoXZoG8ATsAtzS2M4FFF9vpc5thde5aVpvMz0H443DHyv1BpsGJ13lOwsFnmR1_8LiBKrKnaKDMqscnG3uEL2PH9-SSTB7fpomD7NAUyl9oGgYZnkehXEsc6IKrXUhNIe4iJnSZS4zkZcUQqIEiSPKBGeSgRCiVEVYlJIP0dU6d2Hbrw6cT2vjdN8ga6CvnyoumSKK9eLtWtS2dc5CmS6sqTP7k1KSrvZNd_v28sUmtctrKHbq36A9vlzjT-db-08ZoZLwiPNfrf9_oQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83728082</pqid></control><display><type>article</type><title>Persistent Infection with Bovine Herpesvirus-1 (Infectious Bovine Rhinotracheitis Virus) in Cultured Hamster Cells</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>Springer Online Journal Archives</source><creator>Michalski, F. J. ; Hsiung, G. D.</creator><creatorcontrib>Michalski, F. J. ; Hsiung, G. D.</creatorcontrib><description>Bovine herpesvirus-1 infection in hamster embryo cells was found to be dependent upon input multiplicity; productive infection was achieved at input multiplicities greater than one, while persistent infection was established when input multiplicities were about 0.5. This persistence was characterized by a noncyclic, minimal degree of cytopathic effect with a low level of released virus. Maintenance of the persistently infected cultures did not require external supportive measures. Subcultivation of the persistently infected cultures led to virus replication followed by CPE and then cell regrowth. Within 3 to 4 weeks after subcultivation a persistent infection was re-established. The possible mechanism for the bovine herpesvirus persistence in hamster cells is discussed.</description><identifier>ISSN: 0073-5655</identifier><identifier>EISSN: 1475-2689</identifier><identifier>DOI: 10.1007/BF02797471</identifier><identifier>PMID: 190164</identifier><language>eng</language><publisher>United States: Tissue Culture Association, Inc</publisher><subject>Animals ; Cell culture techniques ; Cell growth ; Cell lines ; Cricetinae ; Culture Techniques ; Cultured cells ; Cytopathogenic Effect, Viral ; Embryonic cells ; Fibroblasts ; Herpesviridae ; Herpesvirus 1, Bovine - growth &amp; development ; Herpesvirus 1, Bovine - isolation &amp; purification ; Infections ; L cells ; Mesocricetus ; Ungulates ; Virus Replication ; Viruses</subject><ispartof>In Vitro, 1976-10, Vol.12 (10), p.682-686</ispartof><rights>Copyright 1976 Tissue Culture Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c177t-8144abb64997b08dcccd5c3e9d928cfb7a5bf1e40850961253272e555f8d4df73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/20170363$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/20170363$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,58219,58452</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/190164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Michalski, F. J.</creatorcontrib><creatorcontrib>Hsiung, G. D.</creatorcontrib><title>Persistent Infection with Bovine Herpesvirus-1 (Infectious Bovine Rhinotracheitis Virus) in Cultured Hamster Cells</title><title>In Vitro</title><addtitle>In Vitro</addtitle><description>Bovine herpesvirus-1 infection in hamster embryo cells was found to be dependent upon input multiplicity; productive infection was achieved at input multiplicities greater than one, while persistent infection was established when input multiplicities were about 0.5. This persistence was characterized by a noncyclic, minimal degree of cytopathic effect with a low level of released virus. Maintenance of the persistently infected cultures did not require external supportive measures. Subcultivation of the persistently infected cultures led to virus replication followed by CPE and then cell regrowth. Within 3 to 4 weeks after subcultivation a persistent infection was re-established. The possible mechanism for the bovine herpesvirus persistence in hamster cells is discussed.</description><subject>Animals</subject><subject>Cell culture techniques</subject><subject>Cell growth</subject><subject>Cell lines</subject><subject>Cricetinae</subject><subject>Culture Techniques</subject><subject>Cultured cells</subject><subject>Cytopathogenic Effect, Viral</subject><subject>Embryonic cells</subject><subject>Fibroblasts</subject><subject>Herpesviridae</subject><subject>Herpesvirus 1, Bovine - growth &amp; development</subject><subject>Herpesvirus 1, Bovine - isolation &amp; purification</subject><subject>Infections</subject><subject>L cells</subject><subject>Mesocricetus</subject><subject>Ungulates</subject><subject>Virus Replication</subject><subject>Viruses</subject><issn>0073-5655</issn><issn>1475-2689</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><recordid>eNpFkEtLw0AUhQfxVasb1wqzEhWi88hkJksbrC0UFFG3IZnc0JE86syk4r83ta1d3cX3ce7hIHROyR0lRN6PxoTJWIaS7qEBDaUIWKTifTToIQ9EJMQxOnHukxBOIkaP0CGNCY3CAbIvYJ1xHhqPp00J2pu2wd_Gz_GoXZoG8ATsAtzS2M4FFF9vpc5thde5aVpvMz0H443DHyv1BpsGJ13lOwsFnmR1_8LiBKrKnaKDMqscnG3uEL2PH9-SSTB7fpomD7NAUyl9oGgYZnkehXEsc6IKrXUhNIe4iJnSZS4zkZcUQqIEiSPKBGeSgRCiVEVYlJIP0dU6d2Hbrw6cT2vjdN8ga6CvnyoumSKK9eLtWtS2dc5CmS6sqTP7k1KSrvZNd_v28sUmtctrKHbq36A9vlzjT-db-08ZoZLwiPNfrf9_oQ</recordid><startdate>19761001</startdate><enddate>19761001</enddate><creator>Michalski, F. J.</creator><creator>Hsiung, G. D.</creator><general>Tissue Culture Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19761001</creationdate><title>Persistent Infection with Bovine Herpesvirus-1 (Infectious Bovine Rhinotracheitis Virus) in Cultured Hamster Cells</title><author>Michalski, F. J. ; Hsiung, G. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c177t-8144abb64997b08dcccd5c3e9d928cfb7a5bf1e40850961253272e555f8d4df73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Animals</topic><topic>Cell culture techniques</topic><topic>Cell growth</topic><topic>Cell lines</topic><topic>Cricetinae</topic><topic>Culture Techniques</topic><topic>Cultured cells</topic><topic>Cytopathogenic Effect, Viral</topic><topic>Embryonic cells</topic><topic>Fibroblasts</topic><topic>Herpesviridae</topic><topic>Herpesvirus 1, Bovine - growth &amp; development</topic><topic>Herpesvirus 1, Bovine - isolation &amp; purification</topic><topic>Infections</topic><topic>L cells</topic><topic>Mesocricetus</topic><topic>Ungulates</topic><topic>Virus Replication</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Michalski, F. J.</creatorcontrib><creatorcontrib>Hsiung, G. D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>In Vitro</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Michalski, F. J.</au><au>Hsiung, G. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent Infection with Bovine Herpesvirus-1 (Infectious Bovine Rhinotracheitis Virus) in Cultured Hamster Cells</atitle><jtitle>In Vitro</jtitle><addtitle>In Vitro</addtitle><date>1976-10-01</date><risdate>1976</risdate><volume>12</volume><issue>10</issue><spage>682</spage><epage>686</epage><pages>682-686</pages><issn>0073-5655</issn><eissn>1475-2689</eissn><abstract>Bovine herpesvirus-1 infection in hamster embryo cells was found to be dependent upon input multiplicity; productive infection was achieved at input multiplicities greater than one, while persistent infection was established when input multiplicities were about 0.5. This persistence was characterized by a noncyclic, minimal degree of cytopathic effect with a low level of released virus. Maintenance of the persistently infected cultures did not require external supportive measures. Subcultivation of the persistently infected cultures led to virus replication followed by CPE and then cell regrowth. Within 3 to 4 weeks after subcultivation a persistent infection was re-established. The possible mechanism for the bovine herpesvirus persistence in hamster cells is discussed.</abstract><cop>United States</cop><pub>Tissue Culture Association, Inc</pub><pmid>190164</pmid><doi>10.1007/BF02797471</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0073-5655
ispartof In Vitro, 1976-10, Vol.12 (10), p.682-686
issn 0073-5655
1475-2689
language eng
recordid cdi_proquest_miscellaneous_83728082
source JSTOR Archival Journals and Primary Sources Collection; Springer Online Journal Archives
subjects Animals
Cell culture techniques
Cell growth
Cell lines
Cricetinae
Culture Techniques
Cultured cells
Cytopathogenic Effect, Viral
Embryonic cells
Fibroblasts
Herpesviridae
Herpesvirus 1, Bovine - growth & development
Herpesvirus 1, Bovine - isolation & purification
Infections
L cells
Mesocricetus
Ungulates
Virus Replication
Viruses
title Persistent Infection with Bovine Herpesvirus-1 (Infectious Bovine Rhinotracheitis Virus) in Cultured Hamster Cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T16%3A30%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Persistent%20Infection%20with%20Bovine%20Herpesvirus-1%20(Infectious%20Bovine%20Rhinotracheitis%20Virus)%20in%20Cultured%20Hamster%20Cells&rft.jtitle=In%20Vitro&rft.au=Michalski,%20F.%20J.&rft.date=1976-10-01&rft.volume=12&rft.issue=10&rft.spage=682&rft.epage=686&rft.pages=682-686&rft.issn=0073-5655&rft.eissn=1475-2689&rft_id=info:doi/10.1007/BF02797471&rft_dat=%3Cjstor_proqu%3E20170363%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c177t-8144abb64997b08dcccd5c3e9d928cfb7a5bf1e40850961253272e555f8d4df73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=83728082&rft_id=info:pmid/190164&rft_jstor_id=20170363&rfr_iscdi=true